GI Signals - Colorectal

Traditional Risk Factors Are Not Associated with the Rise of Early-Onset Colorectal Cancer: An All of Us Study.

Mon, 24 Aug 2026 19:12:09 +0000

Diseases of the colon and rectum. This negative finding reveals that traditional environmental and genetic risk factors do not explain the rising incidence of early-onset colorectal cancer. Do not use their absence to reassure younger patients about CRC risk. Family history remains significantly associated (OR 2.10) and should guide risk assessment. Current risk models are incomplete; novel environmental or early-life exposures likely drive early-onset disease but remain unidentified.

Effectiveness of theory-based WhatsApp chatbot outreach in colorectal cancer screening uptake: a randomized controlled trial.

Mon, 24 Aug 2026 19:12:09 +0000

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. Consider implementing WhatsApp-based chatbot outreach for adults aged 50-75 in your CRC screening program. The intervention delivers health education video and tailored behavior-change messaging based on readiness stage, improving uptake by 8-9 percentage points.

Short- and Long-term Outcomes of Three-Row Versus Two-Row Circular Staplers for Low Colorectal Anastomosis After Total Mesorectal Excision: A Single-Center, Randomized, Single-Blind, Phase III Trial (THREESTAPLER Study).

Thu, 20 Aug 2026 21:35:47 +0000

Diseases of the colon and rectum. No change to current practice. Three-row staplers do not offer a leakage reduction advantage over established two-row technique; continue with two-row circular staplers for low anterior resection.

Liquid Biopsies for Cancer: A Translational Science Review.

Thu, 20 Aug 2026 21:35:47 +0000

JAMA. Consider ctDNA testing for colorectal cancer patients to detect molecular relapse earlier than imaging and to identify molecular variants for therapy selection. However, optimal timing of testing and management of positive results in the absence of imaging abnormalities remain unresolved; implementation should await clarity through guidelines or institutional protocols.

A blood-based test for detection of advanced adenomas and colorectal cancer (DENEB): a multicentre diagnostic accuracy study.

Thu, 20 Aug 2026 21:35:47 +0000

The lancet. Gastroenterology & hepatology. Cannot assess clinical utility without results: sensitivity, specificity, and diagnostic accuracy for advanced adenoma detection are not reported in this incomplete abstract.

Inflammation Hinders Anabolic Potential of Nutritional Support in Cancer: Findings from the PRIMe trial.

Thu, 20 Aug 2026 21:35:47 +0000

The American journal of clinical nutrition. In colorectal cancer (stage II-IV) patients receiving nutritional counseling, target at least 27 grams/day additional protein intake to achieve lean tissue gain. This post-hoc exploratory finding requires prospective validation before practice implementation. IL-6-based personalization is not recommended at this time, as IL-6 is not a standard clinical measure and the proposed effect substantially weakens over 12 weeks.

Day 1 Discharge for All Patients After Minimally Invasive Colon Surgery: A Prospective Cohort Study.

Thu, 20 Aug 2026 21:35:47 +0000

Diseases of the colon and rectum. For elective minimally invasive colon resection without stoma, target Day 1 discharge in eligible patients using predefined clinical criteria. This reduces median length of stay from 3 to 1 day with no increase in 30-day readmissions or severe complications. Gastroenterologists should counsel patients on this possibility and support the pathway in surgical planning and post-operative management.

A simple MRI/PET-derived index predicts relapse-free survival after neoadjuvant chemoradiotherapy in locally advanced rectal cancer.