GI Signals - Pancreas/Biliary

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease.

Mon, 24 Aug 2026 19:12:09 +0000

Gut. Patients with ciliopathy-causing mutations HNF1B or NPHP3, particularly those with kidney disease and pediatric-onset pancreatic disease, develop pancreatic fat accumulation (adipopancreatosis) detectable on MRI; clinical significance and impact on pancreatic function or renal outcomes remain unclear.

Timing of cholecystectomy after acute biliary pancreatitis: Impact of disease severity and biological sex.

Mon, 24 Aug 2026 19:12:09 +0000

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. For mild biliary pancreatitis, early cholecystectomy during index admission remains safe; counsel male patients about anticipated surgical complexity and intensive care utilization. For moderate/severe biliary pancreatitis, particularly in female patients, consider interval cholecystectomy to reduce intensive care duration and hospitalization length. Use disease severity and sex to individualize timing strategies and set realistic expectations for recovery resource needs.

Chemotherapy for Unresectable Pancreatic Cancer Complicated by Disseminated Intravascular Coagulation: A Retrospective Cohort Study.

Mon, 24 Aug 2026 19:12:09 +0000

Pancreas. Recognize tumor-related DIC in APC as a marker of extremely poor prognosis (median 1.3 months versus 10.4 months without DIC). Infection-related DIC outcomes differ from both but specific survival not quantified in this series. In patients with tumor-related DIC, chemotherapy with anticoagulation or antifibrinolytic support achieved transient DIC resolution in 4 of 8 patients in this series; however, resolution was temporary and recurrence occurred with tumor progression. Its independent contribution to improved survival requires cautious interpretation. This is exploratory evidence from a small retrospective cohort; selection criteria not detailed.

Prognostic Utility of the Cachexia Index in Resectable and Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Chemotherapy.

Mon, 24 Aug 2026 19:12:09 +0000

Pancreas. S-CXI may identify high-risk resectable pancreatic cancer patients who could benefit from intensified perioperative multidisciplinary care. However, this retrospective study does not test interventions to improve outcomes in high-risk patients; prospective validation and trials of outcome-improvement strategies are needed before routine clinical use.

Emerging Issue - Fatty Pancreas in Pancreatic Cystic Neoplasms: Results of a Matched Case-Control Study.

Mon, 24 Aug 2026 19:12:09 +0000

Digestive diseases and sciences. Fatty pancreas does not appear to independently increase pancreatic cystic neoplasm risk based on this study. Current PNCL risk stratification using established imaging features and CA 19-9 levels should not change; fatty pancreas should not be incorporated as a risk factor at this time. The non-significant tail trend warrants further investigation but does not yet support modified surveillance or management.

Long-term impact of acute pancreatitis on patients' quality of life: a multi-center prospective study in Japan.

Mon, 24 Aug 2026 19:12:09 +0000

Journal of gastroenterology. Assess physical and social function at 3 months in acute pancreatitis survivors (measurement instruments detailed in source), emphasizing females and those with higher initial disease severity. Patients with lower physical component scores warrant intensive psychosocial support. Important: At 12 months, younger age paradoxically predicts incomplete recovery-do not assume standard age-based recovery trajectories.

Pancreatic exocrine function and morphology following prior malnutrition in Asian and African cohorts: A multi-cohort study.

Thu, 20 Aug 2026 18:40:03 +0000

The American journal of clinical nutrition. Do not screen for exocrine pancreatic insufficiency based on malnutrition history alone. Although pancreatic morphology changes persist in malnutrition survivors (larger pancreases in adults, smaller in children when adjusted for body weight), FE-1-based exocrine function is not significantly impaired decades after malnutrition. This refutes prior famine-study concerns and suggests EPI in these populations is driven by other factors.

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review.

Thu, 20 Aug 2026 18:40:03 +0000

Journal of hepato-biliary-pancreatic sciences. For patients with pathologically confirmed CLC (≥80% ductular iCCA with apical EMA positivity) being evaluated for surgical management, the favorable long-term outcomes in resected patients (median OS 10.8 years, 10-year survival 73.7%) compared to small-duct/large-duct-type iCCA with ductular configuration support optimistic prognostic counseling and prioritization for surgical evaluation in candidates deemed resectable.

Association of subcutaneous adiposity with survival outcomes in advanced biliary tract cancer treated with gemcitabine, cisplatin, and immune checkpoint inhibitor.

Thu, 20 Aug 2026 18:40:03 +0000

Journal of gastroenterology. A prognostic association identified in a small retrospective cohort; does not guide treatment selection, monitoring, or counseling beyond current practice. Potential utility for medical oncologists in risk stratification and future trial design, but not actionable for general gastroenterology practice.

Bile Leak Grade Is Associated with Healing Time and Subsequent Biliary Stricture After Liver Transplantation.

Thu, 20 Aug 2026 21:35:47 +0000

Digestive diseases and sciences. Leak grade predicts stricture risk: 94.7% for high-grade versus 0% for low-grade within 12 months. Use leak grade to risk-stratify and consider intensifying endoscopic surveillance in high-grade leaks, pending prospective validation of specific surveillance protocols.

The Global Immune-Nutrition-Inflammation Index (GINI) in Acute Pancreatitis Severity Assessment: A Comparative Study.

Thu, 20 Aug 2026 21:35:47 +0000

Digestive diseases and sciences. GINI shows promise for early severity stratification in acute pancreatitis, with a high negative predictive value (92% NPV) for excluding moderate-severe disease. Clinical implementation requires the full paper to clarify the index's calculation methodology. This single-center retrospective study requires prospective multicenter validation before adoption into routine practice.

Pancreatic exocrine function and morphology following prior malnutrition in Asian and African cohorts: A multi-cohort study.

Thu, 20 Aug 2026 21:35:47 +0000

Association of subcutaneous adiposity with survival outcomes in advanced biliary tract cancer treated with gemcitabine, cisplatin, and immune checkpoint inhibitor.

Thu, 20 Aug 2026 21:35:47 +0000

Systemic inflammation response index (SIRI) predicts outcomes and chemotherapy benefit in metastatic pancreatic cancer: A study by the PANTHEIA- SEOM group.

Thu, 20 Aug 2026 21:35:47 +0000

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. Calculate SIRI from baseline CBC in newly diagnosed metastatic pancreatic cancer for prognostic stratification. Low values (≤2.3) predict longer survival (14.0 vs 9.2 months median OS), superior progression-free survival (5.9 vs 3.9 months), and higher chemotherapy response (37% vs 25%). Use this objective, CBC-derived marker to inform prognostic counseling and discussions about expected clinical course.

Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records.